3-(3-Methoxy-benzenesulfonylamino)-propionic acid → N-(3-hydroxy-propyl)-3-methoxy-benzenesulfonamide

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Reaction Steps

3-(3-Methoxy-benzenesulfonylamino)-propionic acid (0.755 g, 2.91 mmol), was dissolved in THF (10 mL), cooled in an ice-H2O bath, and treated with borane THF complex (3.49 mL of a 1M solution, 3.49 mmol) with stirring. After warming to room temperature over 1 h, the reaction was cooled in an ice bath, and quenched by dropwise addition of H2O, then partitioned between H2O and CH2Cl2. The aqueous layer was washed with CH2Cl2 (3×20 mL), dried (MgSO4). Filtration and concentration in vacuo gave the title compound which was used without further purification.

Provenance & Evidence