Cesium carbonate → HCID 18629434, compound

Participants

Reaction Steps

N-(3-{[1-(4-Cyano-3-fluoro-phenyl)-1-(4-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-methyl]-amino}-propyl)-3-hydroxy-benzenesulfonamide trifluoroacetate salt (0.105 g, 0.137 mmol) was dissolved in DMF (20 mL) and treated with Cs2CO3 (0.223 g, 0.69 mmol). After 3 h at 80° C., the reaction mixture was concentrated in vacuo, dissolved in H2O: 0.1% TFA (3 mL), purified by RP LC on a Delta PrepPak eluting with 95:5 to 5:95 H2O(0.1%TFA): CH3CN(0.1%TFA) and lyophilized to give the title compound. MS (M+1) 518.

Provenance & Evidence