HRID1060998

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2C(=O)O)cc1

HCID17796572

未命名化合物

结构：O=C(O)C(F)(F)F.O=S(=O)(c1ccc2cc(Cl)ccc2c1)N1CCNCC1

HCID22710058

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)cc2)cc1

HCID22711048

未命名化合物

收率 208.9%

PROCEDURE

实验过程

In a similar manner to Referential Example 12 except for the use of 4-[4-(tert-butoxycarbonylamino)phenylbenzoic acid (150 mg) and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine trifluoroacetate (203 mg) as the raw materials, the reaction was conducted, whereby the title compound (303 mg, 100%) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-03d80faa40264ec9a3a89034db7e2c74
来源数据集: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06525042B1
来源说明: uspto-grants-2003_02

反应 SMILES

[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12](C2C=CC=CC=2C(O)=O)=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].F[C:25](F)(F)[C:26]([OH:28])=O.[Cl:31][C:32]1[CH:33]=[C:34]2[C:39](=[CH:40][CH:41]=1)[CH:38]=[C:37]([S:42]([N:45]1[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]1)(=[O:44])=[O:43])[CH:36]=[CH:35]2>>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:9]2[CH:14]=[CH:13][C:25]([C:26]([N:48]3[CH2:47][CH2:46][N:45]([S:42]([C:37]4[CH:36]=[CH:35][C:34]5[C:39](=[CH:40][CH:41]=[C:32]([Cl:31])[CH:33]=5)[CH:38]=4)(=[O:43])=[O:44])[CH2:50][CH2:49]3)=[O:28])=[CH:11][CH:10]=2)=[CH:11][CH:10]=1)=[O:7])([CH3:2])([CH3:4])[CH3:3]