HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-ethyl 3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]acrylate → (E)-3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]-2-propen-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-ethyl 3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]acrylate | HCID 19694369 | — |
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Product | (E)-3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]-2-propen-1-ol | HCID 19694371 | 90% |
Reaction Steps
In the same manner as in Reference Example 11, (E)-ethyl 3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]acrylate was reduced with diisobutylaluminum hydride to yield (E)-3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]-2-propen-1-ol (yield 90%), which was then recrystallized from ethyl acetate-hexane to yield colorless prisms having a melting point of 145° to 146° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05723479 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-95e24e77c6ef45318b9ed18596119d65 |
| Source note | uspto-grants-1998_03 |