tert-Butyl piperazine-1-carboxylate → 1-[(E)-4-Chlorostyrylsulfonyl)piperazine hydrochloride

HRID 1061005Notes

Reaction equation

HRID 1061005 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:14][C:15]1[CH:26]=[CH:25][C:18](/[CH:19]=[CH:20]/[S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[ClH:14].[Cl:14][C:15]1[CH:16]=[CH:17][C:18](/[CH:19]=[CH:20]/[S:21]([N:1]2[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]2)(=[O:23])=[O:22])=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 5938154(E)-2-(4-chlorophenyl)ethene-1-sulfonyl chloride

Product 1

HCID 227103861-[(E)-4-Chlorostyrylsulfonyl)piperazine hydrochloride

Procedure

In a similar manner to Referential Example 1 except for the use of tert-butyl 1-piperazinecarboxylate and (E)-4-chlorostyrylsulfonyl chloride as the raw materials, the reaction was conducted, whereby the title compound was obtained.

Sources & evidence

ORD record
ord-7602db26409641a99e69a6c49536b6d1
Source dataset
uspto-grants-2003_02
Patent number
US06525042B1

Reaction notes

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