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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1061015Generated: November 3, 2026

Methyl 4-((((1,1-dimethylethoxy)carbonyl)amino)methyl)benzoate → 1-[4-(N-tert-Butoxycarbonylaminomethyl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine

https://huagongshe.com/reaction/1061015

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-((((1,1-dimethylethoxy)carbonyl)amino)methyl)benzoateHCID 14221817—
Reactant1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochlorideHCID 22709766—
Product1-[4-(N-tert-Butoxycarbonylaminomethyl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazineHCID 22710552—

Reaction Steps

In a similar manner to Referential Example 48 except for the use of methyl 4-(N-tert-butoxycarbonylaminomethyl)benzoate and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride, the reaction was conducted, whereby the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06525042B1
Source datasetuspto-grants-2003_02
ORD IDord-bd139411cef3492d9d47633358372db5
Source noteuspto-grants-2003_02