Pyridine → 2,5-difluoro-N-(3-{1-(4-methoxybenzyl)-4-[2-(methylamino)-pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)benzenesulfonamide

HRID 106102Notes

Reaction equation

HRID 106102 reaction equation
[F:30][c:31]1[c:32]([S:38](=[O:39])(=[O:40])[Cl:41])[cH:33][c:34]([F:37])[cH:35][cH:36]1.[NH2:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][n:10]([CH2:21][c:22]3[cH:23][cH:24][c:25]([O:28][CH3:29])[cH:26][cH:27]3)[cH:11][c:12]2-[c:13]2[cH:14][c:15]([NH:19][CH3:20])[n:16][cH:17][cH:18]2)[cH:5][cH:6][cH:7]1.[cH:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1>>[NH:1]([c:2]1[cH:3][c:4](-[c:8]2[n:9][n:10]([CH2:21][c:22]3[cH:23][cH:24][c:25]([O:28][CH3:29])[cH:26][cH:27]3)[cH:11][c:12]2-[c:13]2[cH:14][c:15]([NH:19][CH3:20])[n:16][cH:17][cH:18]2)[cH:5][cH:6][cH:7]1)[S:38]([c:32]1[c:31]([F:30])[cH:36][cH:35][c:34]([F:37])[cH:33]1)(=[O:39])=[O:40]

Participants

4

Reactant 3

HCID 1049PyridineHCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 671862484-[3-(3-aminophenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-N-methylpyridin-2-amine

Product 1

HCID 671845852,5-difluoro-N-(3-{1-(4-methoxybenzyl)-4-[2-(methylamino)-pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)benzenesulfonamide

Sources & evidence

ORD record
ord-d263789039b34182a9f2e0c6a47f1090
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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