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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1061028Generated: November 2, 2026

tert-butyl 2-formyl-4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate → 1-[(5-tert-Butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl]methyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine

https://huagongshe.com/reaction/1061028

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl 2-formyl-4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylateHCID 11845085—
Reactant1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochlorideHCID 22709766—
Product1-[(5-tert-Butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl]methyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazineHCID 22710093—

Reaction Steps

In a similar manner to Referential Example 47 except for the use of 5-tert-butoxycarbonyl-2-formyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride as the raw materials, the reaction was conducted, whereby the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06525042B1
Source datasetuspto-grants-2003_02
ORD IDord-db1bdf3868aa499b92d629621f710539
Source noteuspto-grants-2003_02