1-[(E)-4-Chlorostyrylsulfonyl)piperazine hydrochloride → 1-[(E)-4-Chlorostyrylsulfonyl]-4-[(thiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine hydrochloride

HRID 1061071Notes

Reaction equation

HRID 1061071 reaction equation
[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[S:3][C:2]=1[C:10]([O-:12])=O.[Na+].Cl.[Cl:15][C:16]1[CH:32]=[CH:31][C:19](/[CH:20]=[CH:21]/[S:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)(=[O:24])=[O:23])=[CH:18][CH:17]=1>>[ClH:15].[Cl:15][C:16]1[CH:17]=[CH:18][C:19](/[CH:20]=[CH:21]/[S:22]([N:25]2[CH2:30][CH2:29][N:28]([C:10]([C:2]3[S:3][C:4]4[CH:5]=[N:6][CH:7]=[CH:8][C:9]=4[N:1]=3)=[O:12])[CH2:27][CH2:26]2)(=[O:23])=[O:24])=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 227103861-[(E)-4-Chlorostyrylsulfonyl)piperazine hydrochlorideHCID 23694146Sodium thiazolo[5,4-c]pyridine-2-carboxylate

Product 1

HCID 227109051-[(E)-4-Chlorostyrylsulfonyl]-4-[(thiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine hydrochloride

Procedure

In a similar manner to Example 4 except for the use of sodium thiazolo[5,4-c]pyridine-2-carboxylate and 1-[(E)-4-chlorostyrylsulfonyl)piperazine hydrochloride as the raw materials, the reaction was conducted, whereby the title compound was obtained.

Sources & evidence

ORD record
ord-fb7e42bb05a148218108064bf1f26b7d
Source dataset
uspto-grants-2003_02
Patent number
US06525042B1

Reaction notes

Loading…