Ammonia → (+-)-1-Aminoindan

HRID 1061116Notes

Reaction equation

HRID 1061116 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:3](=O)[CH2:2]1.[NH3:11].[H][H]>>[NH2:11][CH:3]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1][CH2:2]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 67351-IndanoneHCID 178418361HCID 178418361, compound

Product 1

HCID 123445(+-)-1-AminoindanYield 91.8%

Procedure

A continuously operated high-pressure reactor was packed with 250 cm3 of catalyst A and, at 130° C. and 100 bar, charged hourly from the base with 32 g of a methanolic α-indanone solution (80% by weight indanone), 55 ml of liquid ammonia and 15 1 (Stp) of hydrogen. Excess ammonia and methanol were then distilled off. The collected discharges from the reaction were analyzed by gas chromatography: 1-aminoindane was obtained in a yield of 91.8%.

Workup

  1. distillationExcess ammonia and methanol were then distilled off

Sources & evidence

ORD record
ord-3b2ab1614f7e418c8ea717344e768596
Source dataset
uspto-grants-2003_02
Patent number
US06525222B2

Reaction notes

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