Thionyl Chloride → Benzeneacetyl chloride, 4-bromo-

HRID 1061146Notes

Reaction equation

HRID 1061146 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:14])=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([Cl:14])=[O:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 74654Benzeneacetic acid, 4-bromo-

Product 1

HCID 181552Benzeneacetyl chloride, 4-bromo-Yield 100%

Procedure

A solution of 50.0 g (232 mmol) of 4-bromophenylacetic acid in 150 mL of thionyl chloride was stirred at room temperature for 18 h. The mixture was concentrated in vacuo to afford 54 g (100%) of the title compound.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-3f39691263e34e3ca65cac97fb732342
Source dataset
uspto-grants-2003_02
Patent number
US06525099B1

Reaction notes

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