HCID 86584546, compound → HCID 69654868, compound

Participants

Reaction Steps

A mixture of N-[5-((1R)-2-azido-1-hydroxy-ethyl)-2-benzyloxy-phenyl]-benzenesulfonamide (1.4 g, 3.3 mmol) (which was obtained in Example 31), HCO2NH4 (2.08 g, 3.3 mmol), and 10% Pd/C in absolute ethanol (15 mL) under nitrogen atmosphere was heated under reflux for 2.5 hours. The mixture was cooled to room temperature, filtered through celite pad, and filtrate concentrated and placed under high vacuum to give the titled compound as yellow solid (0.7 g, 69%); 1H NMR (300 MHz, DMSO-d6) δ 2.74 (d, J=15 Hz, 2H), 4.51 (d, J=6 Hz, 1H), 6.63 (d, J=9 Hz, 1H), 6.76 (d, J=9 Hz, 1H), 7.12 (s, 1H), 7.47 (m, 4H), 7.72 (d, J=6 Hz, 2H).

Provenance & Evidence