5-[4-(4-Oxo-piperidin-1-yl)-benzyl]-thiazolidine-2,4-dione → HCID 131723780, compound

Participants

Reaction Steps

The title compound was prepared from 5-[4-(4-oxo-piperidine-1-yl)-benzyl]-thiazolidine-2,4-dione (which was obtained in Example 38) and propane-2-sulfonic acid [5-((1 R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-amide (which was obtained in Example 27) according to the procedure of Example 73 as a white solid; mp >175° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.25 (d, J=6.8 Hz, 6H), 1.30-1.55 (m, 2H), 1.80-2.00 (m, 2H), 2.60-3.70 (m, 9H), 4.47 (dd, J=9.7, 3.9 Hz, 1H), 4.58 (dd, J=8.7, 3.4 Hz, 1H), 6.75-6.90 (m, 3H), 6.90-7.10 (m, 3H), 7.26 (d, J=2.0 Hz, 1H); MS (ES) m/z: 563.0 (MH+, 100%); HRMS Calcd. for C26H35N4O6S2 (MH+): 563.1992. Found: 563.1985.

Provenance & Evidence