(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 10231287, compound

Participants

Reaction Steps

The title compound was prepared from ethyl{5-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)phenyl]-1H-tetraazol-1-yl}acetate (which was obtained in Example 48) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedures of Example 34 and Example 73 as a white solid; mp >140° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.17 (t, J=7.1 Hz, 3H), 1.20-1.40 (m, 2H), 1.80-1.95 (m, 2H), 2.50-3.50 (m, 5H), 2.89 (s, 3H), 3.70-3.90 (m, 2H), 4.11 (q, J=7.1 Hz, 2H), 4.47 (dd, J=7.8, 4.4 Hz, 1H), 5.60 (brs, 2H), 6.79 (d, J=8.2 Hz, 1H), 6.96 (dd, J=8.2, 2.0 Hz, 1H), 7.07 (d, J=8.9 Hz, 2H), 7.16 (d, J=2.0 Hz, 1H), 7.56 (d, J=8.9 Hz, 2 H); MS (ES) m/z: 560.2 (MH+); HRMS Calcd. for C21H28N7O4S(MH+): 560.2286. Found: 560.2282.

Provenance & Evidence