HCID 86584558, compound → HCID 22843300, compound

Participants

Reaction Steps

A mixture of N-{4-[(1S)-azido-1-hydroxyethyl]phenyl}methanesulfonamide (which was obtained in Example 113) (0.55 g, 2.146 mmol), 10% Pd/C (0.03 g) and methanol (30 mL) was hydrogenated on a Parr shaker at 50 psi for 3 hours. The catalyst was removed by filtration through celite. The filtrate was concentrated under vacuo to give an off-white solid (0.48 g, 97% yield); MS (ES) m/z: 231 (MH+); 1H NMR (400 MHz, DMSO-d6) δ 2.57 (m, 2H), 2.94 (s, 3H), 3.4-4.2 (br, 2H), 4.38 (m, 1H), 4.6-5.8 (br, 2H), 7.23 (d, 2H), 7.26 (d, 2H).

Provenance & Evidence