HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Bromoacetyl)pyridine hydrobromide → (S)-3-Oxiranyl-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Bromoacetyl)pyridine hydrobromide | HCID 2776234 | — |
| Reactant | (R)-2-Methyl-CBS-oxazaborolidine | HCID 9838490 | — |
| Product | (S)-3-Oxiranyl-pyridine | HCID 13319559 | — |
Reaction Steps
The title compound was prepared from (R)-2-methyl-CBS-oxazaborolidine monohydrate and 3-(2-bromoacetyl)pyridine hydrobromide in substantially the same manner, as described in Example 123. The product was obtained as an oil; 1H NMR (300 MHz, DMSO-d6) δ 2.94-2.97 (m, 1H), 3.14-3.17 (m, 1H), 3.99-4.01 (m, 1H), 7.36-7.40 (m, 1H), 7.63-7.66 (m, 1H), 8.51-8.55 (m, 2H); MS (ES) m/z: 121 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06525202B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-c43fc37af9f344afa0de9adffd22f519 |
| Source note | uspto-grants-2003_02 |