(S)-3-Oxiranyl-pyridine → (R)-2-amino-1-(pyridin-3-yl)ethanol

Participants

Reaction Steps

The title compound was prepared from 3-[(2R)-oxiranyl]pyridine (which was obtained in Example 134) and saturated ammonium methanol in substantially the same manner, as described in Example 124. The product was obtained as a brown oil; 1H NMR (300 MHz, DMSO-d6) δ 1.70 (brs, 2H), 2.62-2.74 (m, 2H), 4.46-4.50 (m, 1H), 5.20 (brs, 1H), 7.30-7.34 (m, 1H), 7.68-7.71 (m, 1H), 8.42-8.50 (m, 2H); MS (ES) m/z: 139 (MH+).

Provenance & Evidence