反应详情

1-[4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-phenyl]-ethanone (2.61 g, 10 mmol) (Taylor, E. C., Skotnicki, J. S. Synthesis, 1981, 606) was added to a solution of thallium trinitrate trihydrate (4.44 g, 10 mmol) (McKillop, A., Swann, B. P., Taylor, E. C. J. Am. Chem. Soc., 1971, 93, 4919) in methanol (40 mL) and methylene chloride (20 mL) containing perchloric acid (70%, 10 mL). After 5 hours at room temperature the precipitated thallium (I) nitrate was removed by filtration, and the filtrate was diluted with water (100 mL). The organic phase was separated, the aqueous layer was extracted with methylene chloride, and the combined organic phases were washed with water, dried over sodium sulfate and concentrated. The residue was dissolved in concentrated hydrochloric acid (250 mL) at room temperature. After 3 hours the solution pH was adjusted to 5 by ˜28% ammonium hydroxide. The aqueous layer was extracted with methylene chloride, and the combined organic phases were washed with water, dried over sodium sulfate and concentrated. The product was purified by chromatography on silica gel with ethyl acetate/hexanes eluant to give the title compound as a pale yellowish solid (0.4 g, 17%); 1H NMR (300 MHz, DMSO-d6) δ 2.42 (t, J=6.0 Hz, 4H), 3.41 (s, 2H), 3.56 (t, J=6.0 Hz, 4H), 6.98 (d, J=8.7 Hz, 2H), 7.12 (d, J=8.7 Hz, 2H), 12.20 (s, 1H); MS (ES) m/z: 234.3 (MH+); HRMS Calcd. for C13H15NO3 (M+): 233.1052. Found: 233.1045.

1. customAfter 5 hours at room temperature the precipitated thallium (I) nitrate was removed by filtration
2. additionthe filtrate was diluted with water (100 mL)
3. customThe organic phase was separated
4. extractionthe aqueous layer was extracted with methylene chloride
5. washthe combined organic phases were washed with water
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated
8. dissolutionThe residue was dissolved in concentrated hydrochloric acid (250 mL) at room temperature
9. extractionThe aqueous layer was extracted with methylene chloride
10. washthe combined organic phases were washed with water
11. dry with materialdried over sodium sulfate
12. concentrationconcentrated
13. customThe product was purified by chromatography on silica gel with ethyl acetate/hexanes eluant