beta-Alanine, ethyl ester, hydrochloride → 3-[4-(4-Oxo-piperidin-1-yl)-benzoylamino]-propionic acid ethyl ester

Participants

Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidine-1-yl)-benzoic acid (which was obtained in Example 151) and beta-alanine ethyl ester hydrochloride according to the procedure of Example 154 as a yellowish solid; 1H NMR (300 MHz, CDCl3) δ 1.28 (t, J=7.1 Hz, 3H), 2.56 (t, J=6.1 Hz, 4H), 2.64 (t, J=5.7 Hz, 2H), 3.55-3.65 (m, 6H), 4.15 (q, J=7.1 Hz, 2H), 6.82 (t, J=5.7 Hz, 1H), 6.95 (d, J=8.9 Hz, 2H), 7.70 (d, J=8.9 Hz, 2H); MS (ES) m/z: 319.1 (MH+).

Provenance & Evidence