Ethyl L-valinate hydrochloride → HCID 10712597, compound

Participants

Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidine-1-yl)-benzoic acid (which was obtained in Example 151) and L-valine ethyl ester hydrochloride according to the procedure of Example 154 as a pale yellowish solid; 1H NMR (300 MHz, DMSO-d6) δ 0.93 (d, J=6.8 Hz, 3H), 0.97 (d, J=6.8 Hz, 3H), 1.20 (t, J=7.1 Hz, 3H), 2.10-2.30 (m, 1H), 2.43 (t, J=6.0 Hz, 4H), 3.72 (t, J=6.0 Hz, 4H), 4.00-4.30 (m, 4H), 4.46 (t, J=5.1 Hz, 1H), 7.05 (d, J=8.9 Hz, 2H), 7.82 (d, J=8.9 Hz, 2H), 8.21 (d, J=7.9 Hz, 1H); MS (ES) m/z: 347.3 (MH+); HRMS Calcd. for C19H26N2O4 (M+): 346.1892. Found: 346.1896.

Provenance & Evidence