Methyl L-phenylalaninate hydrochloride → HCID 10523822, compound

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Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidine-1-yl)-benzoic acid (which was obtained in Example 151) and L-phenylalanine methyl ester hydrochloride according to the procedure of Example 154 as a pale yellowish solid; 1H NMR (300 MHz, DMSO-d6) δ 2.41 (t, J=6.0 Hz, 4H), 3.05-3.20 (m, 2H), 3.71 (t, J=6.0 Hz, 4H), 4.55-4.65 (m, 1H), 6.97 (d, J=8.9 Hz, 2H), 7.10-7.45 (m, 5H), 7.73 (d, J=8.9 Hz, 2H), 8.52 (d, J=7.8 Hz, 1H); MS (ES) m/z: 381.3 (MH+); HRMS Calcd. for C22H25N2O4 (MH+): 381.1809. Found: 380.1807.

Provenance & Evidence