L-Leucine, ethyl ester, hydrochloride (1:1) → 4-Methyl-(2S)-2-[4-(4-oxo-piperidin-1-yl)-benzoylamino]-pentanoic acid ethyl ester

Participants

Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidine-1-yl)-benzoic acid (which was obtained in Example 151) and L-leucine ethyl ester hydrochloride according to the procedure of Example 154 as a white flake; 1H NMR (300 MHz, CDCl3) δ 0.99 (t, J=6.2 Hz, 6H), 1.30 (t, J=7.1 Hz, 3H), 1.60-1.80 (m, 3H), 2.56 (t, J=6.0 Hz, 4H), 3.72 (t, J=6.0 Hz, 4H), 4.22 (q, J=7.1 Hz, 2H), 4.80-4.90 (m, 1H), 6.42 (d, J=8.2 Hz, 1H), 6.94 (d, J=7.0 Hz, 2H), 7.77 (d, J=7.0 Hz, 1H); MS (ES) m/z: 361.3 (MH+); HRMS Calcd. for C20H28N20O4 (M+): 360.2049. Found: 360.2081.

Provenance & Evidence