Leucine methyl ester hydrochloride → HCID 69654989, compound

Participants

Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidine-1-yl)-benzoic acid (which was obtained in Example 151) and L-leucine methyl ester hydrochloride according to the procedure of Example 154 as a gum; 1H NMR (300 MHz, CDCl3) δ 0.96 (t, J=6.2 Hz, 6H), 1.60-1.80 (m, 3H), 2.57 (t, J=6.1 Hz, 4H), 3.71 (t, J=6.1 Hz, 4H), 3.77 (s, 3H), 4.80-4.90 (m, 1H), 6.40 (d, J=8.2 Hz, 1H), 6.94 (d, J=7.0 Hz, 2H), 7.75 (d, J=7.0 Hz, 1H); MS (ES) m/z: 347.4 (MH+); HRMS Calcd. for C19H26N2O4 (M+): 346.1892. Found: 346.1881.

Provenance & Evidence