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L-Leucinol → 4-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Leucinol | HCID 111307 | — |
| 反応物 | 4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid | HCID 15948425 | — |
| 生成物 | 4-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-benzamide | HCID 69654770 | — |
反応手順
The title compound was prepared from 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-benzoic acid (which was obtained in Example 150) (0.53 g, 2 mmol) and (S)-leucinol (0.30 g, 2.5 mmol) according to the procedure shown for Example 154 to give 0.53 g of a white solid; m.p. 90-91° C.; MS (ES) m/z: 363.3 (MH+); HRMS (ES) Calcd. for C20H31N2O4 (MH+): 363.2278, Found: 363.2275.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06525202B2 |
| 出典データセット | uspto-grants-2003_02 |
| ORD ID | ord-5954ec8ea2c24874887154add3d2d907 |
| 出典メモ | uspto-grants-2003_02 |