(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 9803765, compound

Participants

Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidine-1-yl)-benzoic acid (which was obtained in Example 151) and N-[5-((1R)-2-amino-1-hydroxy- ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 179 as a white solid; ; mp >85° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.20-1.40 (m, 2H), 1.80-1.95 (m, 2H), 2.60-3.00 (m, 5H), 2.92 (s, 3H), 3.75-3.85 (m, 2H), 4.53 (dd, J=8.3, 4.0 Hz, 1H), 6.82 (d, J=8.3 Hz, 1H), 6.92 (d, J=8.9 Hz, 2H), 7.01 (dd, J=8.3, 2.0 Hz, 1H), 7.19 (d, J=2.0 Hz, 1H), 7.73 (d, J=8.9 Hz, 2H); MS (ES) m/z: 449.9 (MH+); HRMS Calcd. for C21H26N3O6S(M−H)−: 448.1549. Found: 448.1541.

Provenance & Evidence