HCID 10751302, compound → 4-{4-[2-Hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-benzamide

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Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidine-1-yl)-benzamide (which was obtained in Example 147) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 180 as a white solid; mp >75° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.2-1.40 (m, 2H), 1.70-1.90 (m, 2H), 2.55-2.95 (m, 5H), 2.97 (s, 3H), 3.70-3.85 (m, 2H), 4.48 (dd, J=8.0, 4.3 Hz, 1H), 6.81 (d, J=8.2 Hz, 1H), 6.91 (d, J=9.0 Hz, 2H), 6.99 (dd, J=8.2, 2.0 Hz, 1H), 7.17 (d, J=2.0 Hz, 1H), 7.67 (br s, 2H), 7.72 (d, J=9.0 Hz, 2H); MS (ES) m/z: 448.9 (MH+); HRMS Calcd. for C21H29N4O5S(MH+): 449.1853. Found: 449.1853.

Provenance & Evidence