(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 69655138, compound

Participants

Reaction Steps

The title compound was prepared from 3-[4-(4-oxo-piperidine-1-yl)-benzoylamino]-propionic acid benzyl ester (which was obtained in Example 159) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 179 as a white solid; mp >170° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.20-1.45 (m, 2H), 1.80-1.95 (m, 2H), 2.43 (t, J=7.0 Hz, 2H), 2.60-2.90 (m, 5H), 2.90 (s, 3H), 3.00-3.40 (m, 2H), 3.70-3.85 (m, 2H), 4.50 (dd, J=8.0, 4.2 Hz, 1H), 6.82 (d, J=8.3 Hz, 1H), 6.92 (d, J=8.9 Hz, 2H), 7.01 (dd, J=8.3, 1.9 Hz, 1H), 7.18 (d, J=1.9 Hz, 1H), 7.68 (d, J=8.9 Hz, 2H), 8.26 (t, J=5.2 Hz, 1H); MS (ES) m/z: 521.2 (MH+); HRMS Calcd. for C24H33N4O7S(MH+): 521.2064. Found: 521.2056.

Provenance & Evidence