Sodium Hydroxide → HCID 10008017, compound

Participants

Reaction Steps

The title compound was prepared from 2-(4-{4-[2-hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidine-1-yl}-benzoylamino)-4-methyl-pentanoic acid ethyl ester (which was obtained in Example 198) by sodium hydroxide hydrolysis as a white solid; mp >177° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 0.87 (d, J=6.3 Hz, 3H), 0.90 (d, J=6.3 Hz, 3H), 1.35-1.75 (m, 5H), 1.90-2.00 (m, 2H), 2.60-2.90 (m, 5H), 2.94 (s, 3H), 3.65-3.80 (m, 2H), 4.25-4.35 (m, 1H), 4.60-4.65 (m, 1H), 6.85 (d, J=8.3 Hz, 1H), 6.90 (d, J=8.9 Hz, 2H), 7.05 (dd, J=8.3,1.9 Hz, 1H), 7.21 (d, J=1.9 Hz, 1H), 7.73 (d, J=8.9 Hz, 2H), 7.98 (d, J=7.7 Hz, 1H); MS (ES) m/z: 561.3 (M-H)−; HRMS Calcd. for C27H37N4O7S(M−H)−: 561.2377. Found: 561.2381.

Provenance & Evidence