Sodium Hydroxide → HCID 10651147, compound

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Reaction Steps

The title compound was prepared from (2S)-2-(4-{4-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidine-1-yl}-benzoylamino)-3-phenyl-propionic acid methyl ester(which was obtained in Example 204) by sodium hydroxide hydrolysis as a pale yellowish solid; mp >160° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.40-1.50 (m, 2H), 1.90-2.05 (m, 2H), 2.50-3.50 (m, 7H), 2.95 (s, 3H), 3.69-3.75 (m, 2H), 4.30-4.45 (m, 2H), 4.70-4.75 (m, 1H), 6.83 (d, J=8.8 Hz, 2H), 6.88 (d, J=8.3 Hz, 1H), 7.05-7.30 (m, 7H), 7.63 (d, J=8.8 Hz, 2H), 7.93 (br d, J=6.6 Hz, 1H); MS (ES) m/z: 597.1 (MH+); HRMS Calcd. for C30H35N4O7S(M−H)−: 595.2231. Found: 595.2232.

Provenance & Evidence