(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 69655049, compound

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Reaction Steps

The title compound was prepared from methyl 4-methyl-2-[(2S)-4-(4-oxo-piperidine-1-yl)-benzoylamino]-pentanoic acid methyl ester(which was obtained in Example 166) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 180 as a white solid; mp >90° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 0.86 (d, J=6.4 Hz, 3H), 0.92 (d, J=6.4 Hz, 3H), 1.20-1.40 (m, 2H), 1.50-1.95 (m, 5H), 2.55-2.92 (m, 5H), 2.91 (s, 3H), 3.62 (s, 3H), 3.70-3.85 (m, 2H), 4.40-4.55 (m, 2H), 6.82 (d, J=8.2 Hz, 1H), 6.93 (d, J=8.9 Hz, 2H), 7.00 (dd, J=8.2, 2.0 Hz, 2H), 7.18 (d, J=2.0 Hz, 1H), 7.75 (d, J=8.9 Hz, 2H), 8.34 (d, J=7.7 Hz, 1H); MS (ES) m/z: 577.3 (MH+); HRMS Calcd. for C28H41N4O7S(MH+): 577.2690. Found: 577.2682.

Provenance & Evidence