(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 69654930, compound

Participants

Reaction Steps

The title compound was prepared from N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-4-(4-oxo-1-piperidineyl)benzamide (which was obtained in Example 173) (0.13 g, 0.4 mmol) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (0.12 g, 0.48 mmol) (which was obtained in Example 10) according to the prodedure shown for Example 180 to give 0.16 g of an off-white solid; m.p. 120-122° C.; MS (ES) m/z: 549.3 (MH+); HRMS (ES) Calcd. for C27H41N4O6S(MH+): 549.2741, Found: 549.2735.

Provenance & Evidence