1-Octanesulfonyl chloride → Octane-1-sulfonic acid [4-(4-oxo-1-piperidineyl)-phenyl]-amide

Participants

Reaction Steps

The title compound was prepared from 1-octanesulfonyl chloride and 1-(4-amino-phenyl)-piperidine-4-one hydrochloride (which was obtained in Example 224) according to the procedure B of Example 225 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.84 (t, J=5.4 Hz, 3H), 1.15-1.40 (m, 10H), 1.60-1.75 (m, 2H), 2.40 (t, J=4.5 Hz, 4H), 2.94 (t, J=5.7 Hz, 2H), 3.54 (t, J=4.5 Hz, 4H), 6.99 (d, J=6.9 Hz, 2H), 7.09 (d, J=6.9 Hz, 2H), 9.31 (s, 1H); MS (ES) m/z: 367.0 (MH+); HRMS Calcd. for C19H30N2O2S(M+): 366.1977. Found: 366.1969. Anal. Calcd. for C19H30N2O2S: C, 62.26; H, 8.25; N, 7.64. Found: C, 62.40; H, 7.98; N, 7.59.

Provenance & Evidence