HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Amino-phenyl)-piperidin-4-one hydrochloride → {4-[4-(4-Oxo-piperidin-1-yl)-phenylsulfamoyl]-phenoxy}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Amino-phenyl)-piperidin-4-one hydrochloride | HCID 22220240 | — |
| Reactant | Methyl 2-[4-(chlorosulfonyl)phenoxy]acetate | HCID 22479292 | — |
| Product | {4-[4-(4-Oxo-piperidin-1-yl)-phenylsulfamoyl]-phenoxy}-acetic acid methyl ester | HCID 69654907 | — |
Reaction Steps
The title compound was prepared from (4-chlorosulfonyl-phenoxy)-acetic acid methyl ester (Chem. Pharm. Bull. 1995, 43, 1132) and 1-(4-amino-phenyl)-piperidine-4-one hydrochloride (which was obtained in Example 224) according to the procedure B of Example 225 as a grey solid; MS (ES) m/z: 418.9 (MH+); HRMS Calcd. for C20H23N2O6S(MH+): 419.1271. Found: 419.1271.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06525202B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-29b060a7a4d244d28dd5ca6d0794c554 |
| Source note | uspto-grants-2003_02 |