4-(Chlorosulfonyl)benzoic acid → 4-[4-(4-Oxo-piperidin-1-yl)-phenylsulfamoyl]-benzoic acid

Participants

Reaction Steps

The title compound was prepared from 4-(chlorosulfonyl)benzoic acid and 1-(4-amino-phenyl)-piperidine-4-one hydrochloride (which was obtained in Example 224) according to the procedure B of Example 225 as a pale grey solid; 1H NMR (300 MHz, DMSO-d6) δ 2.36 (t, J=6.0 Hz, 4H), 3.49 (t, J=6.0 Hz, 4H), 6.87 (d, J=9.3 Hz, 2H), 6.91 (d, J=9.3 Hz, 2H), 7.77 (d, J=8.1 Hz, 2H), 8.04 (d, J=8.1 Hz, 2H), 9.97 (s, 1H), 13.10 (brs, 1H); MS (ES) m/z: 374.9 (MH+); HRMS Calcd. for C18H19N2O5S(MH+): 375.1009. Found: 375.1009.

Provenance & Evidence