2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester → HCID 69655037, compound

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Reaction Steps

The title compound was prepared from 2-(methoxycarbonyl)thiophene-3-sulphonyl chloride and 1-(4-amino-phenyl)-piperidine-4-one hydrochloride (which was obtained in Example 224) according to the procedure B of Example 225 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 2.37 (t, J=6.0 Hz, 4H), 3.50 (t, J=6.0 Hz, 4H), 3.89 (s, 3H), 6.90 (d, J=9.1 Hz, 2H), 6.96 (d, J=9.1 Hz, 2H), 7.33 (d, J=6.9 Hz, 1H), 7.90 (d, J=6.9 Hz, 1H), 9.50 (s, 1H); MS (ES) m/z: 395.0 (MH+); HRMS Calcd. for C17H19N2O5S2 (MH+): 395.0736. Found: 395.0721.

Provenance & Evidence