HCID 10354678, compound → HCID 69654808, compound

HRID 1061351Notes

Reaction equation

HRID 1061351 reaction equation
[CH2:1]([O:8][C:9]([CH2:11][S:12](Cl)(=[O:14])=[O:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][C:27](=[O:30])[CH2:26][CH2:25]2)=[CH:20][CH:19]=1>>[CH2:1]([O:8][C:9](=[O:10])[CH2:11][S:12](=[O:14])(=[O:13])[NH:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:25][CH2:26][C:27](=[O:30])[CH2:28][CH2:29]2)=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10354678HCID 10354678, compoundHCID 222202401-(4-Amino-phenyl)-piperidin-4-one hydrochloride

Product 1

HCID 69654808HCID 69654808, compound

Procedure

The title compound was prepared from benzyloxycarbonylmethylsulfonylchloride (J. Antibiot., 1994, 47, 1041) and 1-(4-amino-phenyl)-piperidine-4-one (which was obtained in Example 224) according to the procedure B of Example 225 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 2.42 (t, J=6.0 Hz, 4H), 3.55 (t, J=6.0 Hz, 4H), 4.16 (s, 2H), 5.16 (s, 2H), 6.99 (d, J=9.0 Hz, 2H), 7.10 (d, J=9.0 Hz, 2H), 9.73 (s, 1H); MS (ES) m/z: 403.2 (MH+); HRMS Calcd. for C20H22N2O5S(M+): 402.1250. Found: 402.1237.

Sources & evidence

ORD record
ord-cf30bb42f4fc40498a8a19c0375b1e3c
Source dataset
uspto-grants-2003_02
Patent number
US06525202B2

Reaction notes

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