N-{4-[4-(4-Oxo-piperidin-1-yl)-phenylsulfamoyl]-phenyl}-acetamide → N-(4-{4-[4-((2R)-2-Hydroxy-2-phenyl-ethylamino)-piperidin-1-yl]-phenylsulfamoyl}-phenyl)-acetamide

Participants

Reaction Steps

The title compound was prepared from N-{4-[4-(4-oxo-piperidine-1-yl)-phenylsulfamoyl]-phenyl}-acetamide (which was obtained in Example 216) and (1R)-2-amino-1-(3-chloro-phenyl)-ethanol (which was obtained in Example 1) according to the procedure of Example 255 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.55-1.75 (m, 2H), 2.06 (s, 3H), 2.00-2.15 (m, 2H), 2.50-3.20 (m, 5H), 3.55-3.70 (m, 2H), 4.90-5.00 (m, 1H), 6.00-6.20 (brs, 1H), 6.80 (d, J=9.0 Hz, 2H), 6.89 (d, J=9.0 Hz, 2H), 7.25-7.52 (m, 5H), 7.59 (d, J=8.7 Hz, 2H), 7.70 (d, J=8.7 Hz, 2H), 10.41 (s, 1H); MS (ES) m/z: 509.2 (MH+); HRMS Calcd. for C27H33N4O4S(MH+): 509.2223. Found: 509.2194.

Provenance & Evidence