(+)-Norepinephrine → HCID 69654609, compound

Participants

Reaction Steps

The title compound was prepared from 4-methoxy-N-[4-(4-oxo-piperidine-1-yl)-phenyl]-benzenesulfonamide (which was obtained in Example 218) and L-norepinephrine according to the procedure of Example 255 as a white solid; 1 H NMR (300 MHz, DMSO-d6) δ 1.40-1.55 (m, 2H), 1.90-2.05 (m, 2H), 2.50-3.00 (m, 5H), 3.50-3.75 (m, 2H), 3.79 (s, 3H), 4.50-4.65 (m, 1H), 6.60 (d, J=8.0 Hz, 1H), 6.68 (d, J=8.0 Hz, 1H), 6.76-6.80 (m, 3H), 6.88 (d, J=9.0 Hz, 2H), 7.04 (d, J=7.8 Hz, 2H), 7.61 (d, J=7.8 Hz, 2H), 8.85 (s, 1H); MS (ES) m/z: 513.9 (MH+); HRMS Calcd. for C26H32N3O6S(MH+): 514.2011. Found: 514.2000.

Provenance & Evidence