4-((2S)-3-Amino-2-hydroxy-propoxy)-1,3-dihydrobenzoimidazol-2-one → HCID 69655006, compound

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Reaction Steps

The title compound was prepared from 4-[4-(3-cyclopentyl-propyl)-5-oxo-4,5-dihydro-tetrazol-1-yl]-N-[4-(4-oxo-piperidine-1-yl)-phenyl]-benzenesulfonamide (which was obtained in Example 226) and (S)-4-[2-hydroxy-3-aminopropoxy]-1,3-dihydro-2H-benzimidazol-2-one (U.S. Pat. No. 5,786,356/1998) according to the procedure of Example 255 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.90-4.00 (m, 29H), 5.10-5.30 (m, 1H), 6.58 (d, J=7.9 Hz, 1H), 6.61 (d, J=7.9 Hz, 1H), 6.81 (d, J=8.9 Hz, 2H), 6.89 (d, J=8.9 Hz, 2H), 6.90 (dd, J=7.9, 7.9 Hz, 1H), 7.86 (d, J=8.5 Hz, 2H), 8.07 (d, J=8.5 Hz, 2H), 10.70 (s, 1H), 10.80 (s, 1H); MS (ES) m/z: 732.3 (MH+); HRMS Calcd. for C36H46N9O6S(MH+): 732.3292. Found: 732.3294.

Provenance & Evidence