4-((2S)-3-Amino-2-hydroxy-propoxy)-phenol → N-[4-(4-{[(2S)-2-Hydroxy-3-(4-hydroxyphenoxy)propyl]amino}-1-piperidineyl)phenyl]-1-octanesulfonamide

Participants

Reaction Steps

The title compound was prepared from octane-1-sulfonic acid (4-(4-oxo-piperidine-1-yl)-phenyl]-amide (which was obtained in Example 230) and 4-((2S)-3-amino-2-hydroxy-propoxyl)-phenol (which was obtained in Example 5) according to the procedure of Example 278 as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.85 (t, J=7.0 Hz, 3H), 1.15-1.45 (m, 12H), 1.50-1.70 (m, 2H), 1.80-1.95 (m, 2H), 2.50-2.80 (m, 5H), 2.92 (brt, J=6.7 Hz, 2H), 3.54 (brd, J=12.3 Hz, 2H), 3.70-3.90 (m, 3H), 6.66 (d, J=6.7 Hz, 2H), 6.75 (d, J=8.3 Hz, 1H), 6.88 (d, J=9.0 Hz, 2H), 7.04 (d, J=9.0 Hz, 2H), 8.89 (brs, 1H), 9.28 (brs, 1H); MS (ES) m/z: 534.1 (MH+); HRMS Calcd. for C28H44N3O5S(MH+): 534.3002. Found: 534.3017.

Provenance & Evidence