4-(3-hexyl-ureido)-N-[4-(4-oxo-piperidin-1-yl)-phenyl]-benzenesulfonamide → 4-{[(Hexylamino)carbonyl]amino}-N-{4-[4-({(2S)-2-hydroxy-3-[(8-hydroxy-2-oxo-1,2,3,4-tetrahydro-5-quinolinyl)oxy]propyl}amino)-1-piperidineyl]phenyl}benzenesulfonamide

Participants

Reaction Steps

The title compound was prepared from 4-(3-hexyl-ureido)-N-[4-(4-oxo-piperidine-1-yl)-phenyl]-benzensulfonamide (which was obtained in Example 225) and 5-(3-amino-(2S)-2-hydroxy-propoxy)-8-hydroxy-3,4-dihydro-1H-quinolin-2-one (which was obtained in Example 12) according to the procedure of Example 278 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.86 (t, J=5.1 Hz, 3H), 1.20-1.35 (m, 8H), 1.35-1.50 (m, 2H), 1.75-1.90 (m, 2H), 2.39 (t, J=5.1 Hz, 2H), 2.50-2.75 (m, 5H), 2.82 (t, J=5.1 Hz, 2H), 3.05 (q, J=5.1 Hz, 2H), 3.40-3.55 (m, 2H), 3.75-3.85 (m, 3H), 4.90 (brs, 1H), 6.30 (t, J=5.1 Hz, 1H), 6.44 (d, J=6.6 Hz, 1H), 6.59 (d, J=6.6 Hz, 1H), 6.76 (d, J=6.9 Hz, 1H), 6.85 (d, J=6.9 Hz, 1H), 7.46 (d, J=6.9 Hz, 2H), 7.50 (d, J=6.9 Hz, 2H), 8.67 (s, 1H), 8.84 (s, 1H), 9.10 (brs, 1H), 9.50 (brs, 1H); MS (ES) m/z: 709.2 (MH+); HRMS Calcd. for C36H49N6O7S(MH+): 709.3383. Found: 709.3391.

Provenance & Evidence