HCID 69654832, compound → HCID 69654950, compound

Participants

Reaction Steps

A mixture of 0.18 g of [(butane-1-sulfonyl)-(4-{4-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidine-1-yl}-phenyl)-amino]-acetic acid benzyl ester (which was obtained in Example 342) and 0.05 g of 10% palladium on carbon in 15 mL of methanol was shaken on a Parr hydrogenator at 25 psi overnight. The mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo, which afforded a beige solid; 1H NMR (300 MHz, DMSO-d6) δ 0.86 (t, J=7.23 Hz, 3H), 1.29-1.41 (m, 2H), 1.48-1.51 (m, 2H), 1.54-1.73 (m, 2H), 1.92-2.09 (m, 2H), 2.57-2.64 (m, 2H), 2.79-2.87 (m, 2H), 2.94 (s, 3H), 3.00-3.07 (m, 4H), 3.16 (s, 2H), 3.20-3.26 (m, 2H), 3.64-3.75 (m, 2H), 4.02-4.04 (m, 2H), 4.77-4.81 (m,1H), 6.84-6.91 (m, 3H), 7.06 (dd, J=2.1 Hz, 8.4 Hz, 2H), 7.23 (d, J=1.8 Hz,1H), 7.34 (d, J=9.00 Hz, 2H); MS (ES) m/z: 599.0 (MH+); HRMS found for C26H38N4O8S2: 599.2202.

Provenance & Evidence