3,5-Dichloro-4-(2-chloro-4-nitrophenoxy)benzene-1-sulfonyl chloride → HCID 69654662, compound

HRID 1061410Notes

Reaction equation

HRID 1061410 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[Cl:16][C:17]1[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[CH:33]=[CH:32][C:18]=1[O:19][C:20]1[C:25]([Cl:26])=[CH:24][C:23]([S:27](Cl)(=[O:29])=[O:28])=[CH:22][C:21]=1[Cl:31].[OH:39][C@@H:40]([CH2:53][NH2:54])[CH2:41][O:42][C:43]1[C:51]2[NH:50][C:49](=[O:52])[NH:48][C:47]=2[CH:46]=[CH:45][CH:44]=1>>[Cl:31][C:21]1[CH:22]=[C:23]([S:27]([NH:2][C:3]2[CH:8]=[CH:7][C:6]([N:9]3[CH2:14][CH2:13][CH:12]([NH:54][CH2:53][C@H:40]([OH:39])[CH2:41][O:42][C:43]4[C:51]5[NH:50][C:49](=[O:52])[NH:48][C:47]=5[CH:46]=[CH:45][CH:44]=4)[CH2:11][CH2:10]3)=[CH:5][CH:4]=2)(=[O:29])=[O:28])[CH:24]=[C:25]([Cl:26])[C:20]=1[O:19][C:18]1[CH:32]=[CH:33][C:34]([N+:36]([O-:38])=[O:37])=[CH:35][C:17]=1[Cl:16]

Participants

4

Reactant 3

HCID 27743613,5-Dichloro-4-(2-chloro-4-nitrophenoxy)benzene-1-sulfonyl chlorideHCID 107991054-((2S)-3-Amino-2-hydroxy-propoxy)-1,3-dihydrobenzoimidazol-2-oneHCID 222202401-(4-Amino-phenyl)-piperidin-4-one hydrochloride

Product 1

HCID 69654662HCID 69654662, compound

Procedure

The title compound was prepared from 1-(4-aminophenyl)-4-piperidone hydrochloride (which was obtained in Example 224), 4-(2-chloro-4-nitrophenoxy)-3,5-dichlorobenzenesulfonyl chloride, and (S)-4-[2-hydroxy-3-aminopropoxy]-1,3-dihydro-2H-benzimidazol-2-one (U.S. Pat. No. 5,786,356/1998) according to the procedure of Example 346; MS (ES) m/z: 777.2, 779.2 (MH+).

Sources & evidence

ORD record
ord-b04acc6660d44fe0849858a481dccea0
Source dataset
uspto-grants-2003_02
Patent number
US06525202B2

Reaction notes

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