Sodium Hydroxide → HCID 69654834, compound

Participants

Reaction Steps

The title compound was prepared from ethyl {[(butyl-4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}anilino)carbonyl]amino}acetate (which was obtained in Example 379) by NaOH hydrolysis as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.83 (t, J=7.1 Hz, 3H), 1.15-1.60 (m, 6H), 1.85-2.00 (m, 2H), 2.65-2.95 (m, 5H), 2.92 (s, 3H), 3.42 (d, J=4.0 Hz, 2H), 3.45-3.55 (m, 2H), 3.65-3.80 (m, 2H), 4.65-4.75 (m, 1H), 5.16 (t, J=4.0 Hz, 1H), 6.83 (d, J=8.3 Hz, 1H), 6.95-7.15 (m, 5H), 7.20 (d, J=2.0 Hz, 1H); MS (ES) m/z: 576.3 (M−H)−; HRMS Calcd. for C27H38N5O7S(M−H)−: 576.2497. Found: 576.2502.

Provenance & Evidence