Methanol → HCID 131725197, compound

Participants

Reaction Steps

2-[(4-Pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole (10 g, 33.7 mmol) and fumaric acid (7.8 g, 67.4 mmol) were combined in methanol (100 mL) and stirred at room temperature for 4 hours. The suspension was filtered, washed with isopropanol (60 mL), and dried under reduced pressure to provide the title compound as a solid. Elemental analysis calc'd: C, 59.09; H, 5.39; N, 14.98. Found: C, 58.97; H, 5.22; N, 14.85. DSC: sharp endotherm at 177.26° C., followed by a smaller endotherm at 237.95° C.

Provenance & Evidence