4-Hydroxybenzaldehyde → HCID 22285358, compound

Participants

Reaction Steps

A mixture containing 1-[[2-(2,4-difluorophenyl)-oxiranyl]-methyl]-1H-imidazole (P2) (0.5 g, 2.1 mmole), 4-hydroxy-benzaldehyde (0.31 g, 2.5 mmole) K2CO3 (0.41 g, 2.9 mmole), 18-C-6 (25 mg) in 5 ml of DMF is stirred for 6 hours, extracted with dichloromethane, washed with 2N sodium bicarbonate, dried over Na2SO4, filtered and evaporated under reduced pressure in order to obtain 0.957 g of crude product which is purified by chromatography eluting with a CH2Cl2/MeOH mixture 97/3 in order to obtain 0.557 mg of expected product. Rf=0.12 (CH2Cl2/MeOH 97/3).

Provenance & Evidence