1,4-Dioxane hydrochloride → HCID 69751538, compound

HRID 1061650Notes

Reaction equation

HRID 1061650 reaction equation
[ClH:1].O1CCOCC1.[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[CH:17]([OH:34])[C@@H:18]([NH:26]C(OC(C)(C)C)=O)[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[ClH:1].[NH2:26][C@@H:18]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH:17]([C:9]1[S:8][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=1)[OH:34]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59897116HCID 59897116, compound

Product 1

HCID 69751538HCID 69751538, compound

Procedure

A 4 N hydrogen chloride/dioxane solution (6.3 ml) is added to (1RS,2S)-1-(2-benzothiazolyl)-2-(tert-butoxycarbonyl)amino-3-phenyl-1-propanol (0.64 g, Reference compound No. 9-1) under ice cooling, then the temperature is raised to room temperature, and the mixture is stirred for 30 minutes. The reaction mixture is concentrated under reduced pressure, diethyl ether is added to the residue, and precipitated crystals are filtered off to give the titled reference compound (0.56 g).

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure, diethyl ether
  2. additionis added to the residue
  3. customprecipitated crystals
  4. filtrationare filtered off

Sources & evidence

ORD record
ord-16d2cfd3f0434801a1403be7a490d070
Source dataset
uspto-grants-2005_11
Patent number
US06960575B2

Reaction notes

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