HCID 60073853, compound → HCID 60073857, compound

HRID 1061654Notes

Reaction equation

HRID 1061654 reaction equation
C(OC([NH:11][C@@H:12]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH:13]([OH:23])[CH2:14][O:15][Si:16]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17])=O)C1C=CC=CC=1>CO.[C].[Pd]>[NH2:11][C@@H:12]([CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[CH:13]([OH:23])[CH2:14][O:15][Si:16]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17]

Participants

4

Reactant 1

HCID 60073853HCID 60073853, compound

Product 1

HCID 60073857HCID 60073857, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

5% Palladium-carbon (130 mg) is added to a solution of (2RS,3S)-3-(benzyloxycarbonyl)amino-1-(tert-butyldimethylsilyl)oxy-4-phenyl-2-butanol (130 mg, Reference compound No. 15-1) in methanol (5 ml), and the mixture is stirred under a hydrogen atmosphere (1 atm) for three hours. The reaction mixture is filtered to remove the catalyst. The filtrate is concentrated under reduced pressure to give the titled reference compound (89.2 mg).

Workup

  1. filtrationThe reaction mixture is filtered
  2. customto remove the catalyst
  3. concentrationThe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-7f7088c401374ac4a42505019387c2fc
Source dataset
uspto-grants-2005_11
Patent number
US06960575B2

Reaction notes

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