反应详情

Methanol (50 ml) is cooled to −15° C., then thionyl chloride (21.2 g) is added dropwise to the methanol, and the solution is stirred for 20 minutes. DL-Valine is added to the solution, and the mixture is stirred overnight. The reaction mixture is concentrated under reduced pressure, and diethyl ether is added to the resulting residue to precipitate crystals. The precipitated crystals are filtered off to give the titled reference compound (8.68 g).

1. stirringthe mixture is stirred overnight
2. concentrationThe reaction mixture is concentrated under reduced pressure, and diethyl ether
3. additionis added to the resulting residue
4. customto precipitate crystals
5. filtrationThe precipitated crystals are filtered off