Acetic Anhydride → HCID 22284133, compound

HRID 1061680Notes

Reaction equation

HRID 1061680 reaction equation
[C:1]([O:4][C:5](=O)[CH3:6])(=[O:3])[CH3:2].[C:8]([N:11]1[CH:16]=[C:15]([C:17]2[CH:22]=[C:21]([OH:23])[C:20]([OH:24])=C(O)C=2)[N:14]([CH2:26][C:27]([OH:29])=[O:28])[C:13](=[O:30])[CH:12]1[CH:31]([CH3:33])[CH3:32])(=[O:10])[CH3:9]>CC(C)=O>[C:8]([N:11]1[CH:16]=[C:15]([C:17]2[CH:6]=[C:5]([O:4][C:1](=[O:3])[CH3:2])[C:20]([O:24][C:1](=[O:3])[CH3:2])=[C:21]([O:23][C:5](=[O:4])[CH3:6])[CH:22]=2)[N:14]([CH2:26][C:27]([OH:29])=[O:28])[C:13](=[O:30])[CH:12]1[CH:31]([CH3:33])[CH3:32])(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22284342HCID 22284342, compound

Product 1

HCID 22284133HCID 22284133, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Acetic anhydride is added to a suspension of {(3RS)-4-acetyl-3-isopropyl-2-oxo-6-(3,4,5-trihydroxyphenyl)-1,2,3,4-tetrahydropyrazin-1-yl}acetic acid (630 mg, Reference compound No. 62-2) in acetone (10 ml), and the mixture is stirred for one week. The reaction mixture is concentrated under reduced pressure to give the titled reference compound (790 mg).

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-c3734e76eb324bb6b149e7e645a6c57e
Source dataset
uspto-grants-2005_11
Patent number
US06960575B2

Reaction notes

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